The North Fork of the Edisto is formed by the confluence of Chinquapin Creek and Lightwood Knot Creek. The North Fork meanders about 66 miles to the city of Orangeburg, then turns due south and continues 20 miles to join the South Fork, forming the main stem Edisto River.

Public boating access begins at Poole's Mill Landing, about 67 miles upstream of the confluence with the South Fork. The North Fork is mostly narrow and winding, and may have trees down across the channel, requiring skilled boat manuevering and possible portages. While the channel widens some after Orangeburg, expect to confront some obstacles in the channel. The final public access to the North Fork is Kill Kare Landing, about 2 miles upstream of the confluence.

Adjacent Waterway: downstream, Edisto River.